Harvestainer™ Microcarrier Separation System

Catalog number:SH3107801

Model:Harvestainer™

Brand::Thermo Scientific / Thermo Fisher Scientific – Mỹ

Hotline 024.3783.5922

The Thermo Scientific Harvestainer Microcarrier Separation System is the ideal solution for the separation of microcarrier beads during adherent cell culture production. The Harvestainer system is a closed, single-use system that helps to increase product yields versus traditional methods, while reducing clean-in-place and steam-in-place requirements and water for injection usage. It eliminates equipment maintenance and reduces process validations, cycle times, and manual final decanting processes.

For smaller-scale or larger-scale applications, the Harvestainer system is ideal for in-line microcarrier separation. The 3 L and 12 L Harvestainer systems consist of a pre-assembled bioprocess container (BPC) and tray in a single-use unit, where the tray acts as the secondary containment device. The 25 L and 50 L Harvestainer systems consist of a 3D BPC with a drum as the secondary containment device.

The BPC features a dip tube with dipwell design for better drainage and minimal manipulation.

• Closed system
• Scalable for both smaller-scale and larger-scale applications
• Helps deliver high recovery rates
• Inline microcarrier separation

Adherent cell culture production

Name	Specification
Small-scale:	Harvestainer BPC 3L	Harvestainer BPC 12L
Tray size (H x W x D)	7.11 x 36.6 x 55.25 cm	7.59 x 57.09 x 81.28 cm
Bag size (H x W):	46.94 x 28.96 cm	70.36 x 50.04 cm
Bag weight:	0.11 kg	0.25 kg
Bag surface area:	2.303 cm²	5,909 cm²
Net surface area:	1.000 cm²	2,710 cm²
Tray material thickness	0.18 cm	0.18 cm
Tray material:	PETG	PETG
Input line:	C-Flex tubing; ID x OD: 3/8 x 5/8 in; Polycarbonate quick connect 3/8 in; MPC body & cap.
Output line:	C-Flex tubing; ID x OD: 3/8 x 5/8 in; Polycarbonate quick connect 3/8 in; MPC insert and plug
Large-scale	Harvestainer BPC 25L	Harvestainer BPC 50L
Bag size (H x W):	137.16 x 48.26 x 48.26 cm	137.16 x 48.26 x 48.26 cm
Bag weight:	2.36 kg	2.90 kg
Bag surface area:	20,923 cm²	20,923 cm²
Net surface area:	30,000 cm²	60,000 cm²
Input line:	C-Flex tubing; ID x OD: 1/2 x 5/8 in; Polycarbonate quick connect 1/2 in.; MPX insert & cap.
Output line:	C-Flex tubing; ID x OD: 1/2 x 5/8 in; Polycarbonate quick connect 1/2 in; MPX body and plug
Gas line:	C-Flex tubing; ID x OD: 1/4 x 3/8 in; Pall™ gas filter

MECHANICAL AND PHYSICAL TEST RESULTS

Test	3 L	12 L	25 L	50 L
Microcarrier bead retention	≥ 90 µm
Flow rates	≤ 2.5 L/min	≤ 3.3 L/min	≤ 6.7 L/min	≤ 6.7 L/min
Shipping (ISTA 2A)	Pass
System integrity	Pass
Microcarrier bead capacity	3 L	12 L	25 L	50 L
Secondary containment	Yes	Yes	200 L	200 L
Cell yield	≥ 85%
Cell viability	> 97%
Sterility assurance level (25–40 kGy)	10^-6	10^-6	Pass	Pass
Maximum internal BPC pressure rating	0.5 psi

Product name	Cat. No.
Small-scale
3 L Harvestainer system	SH31078.01
12 L Harvestainer system	SH31078.02
Large-scale
25 L Top-drain Harvestainer system with single 25 L microbarrier BPC	SH31071.01
50 L Top-drain Harvestainer system with dual 25 L microbarrier BPCs	SH31071.02
Accessories
Drum with offset conical insert	SV50517.07
Plastic drum dolly	SV50029.03